Recently, increasing numbers of rare pathogenic genetic variants have been identified that
are associated with variably elevated risks of a range of neurodevelopmental outcomes …

Copy number variants (CNVs) are genomic imbalances strongly linked to the aetiology of
neuropsychiatric disorders such as schizophrenia and autism. By virtue of their large size …

The mechanistic tie between genome-wide association study (GWAS)-implicated risk
variants and disease-relevant cellular phenotypes remains largely unknown. Here, using …

Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …

Patients with schizophrenia experience cognitive dysfunction and negative symptoms that
do not respond to current drug treatments. Historical evidence is consistent with the …

Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of
brain development in a disorder typically diagnosed during early adult life is enigmatic. The …

The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased
worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research …

Agitation is one of the most eminent characteristics of neuropsychiatric symptoms (NPS)
affecting people living with Alzheimer's and Dementia and has serious consequences for …

Introduction Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via
reprogramming techniques. The iPSC approach has been increasingly used in …

The inaccessibility of neurons coming directly from patients has hindered our understanding
of mental illnesses at the cellular level. To overcome this obstacle, six different cellular …