Amyloidoses include a large variety of local and systemic diseases that share the common
feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are …

Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the
human brain, which is the hallmark of many neurodegenerative diseases. Promising …

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …

Insulin aggregation poses a significant problem in pharmacology and medicine as it occurs
during prolonged storage of the hormone and in vivo at insulin injection sites. We have …

Proteins play a major role in the regulation of various cellular functions including the
synthesis of structural components. But proteins are stable under physiological conditions …

In recent years, due to the aging of the population and the development of diagnostic
medicine, the number of identified diseases associated with the accumulation of amyloid …

Protein aggregation is an underlying cause of many neurodegenerative diseases. Also, the
overlapping pathological disturbances between neurodegenerative diseases and type-2 …

The aggregation of Aβ42 is established as a key factor in the development of Alzheimer's
disease (AD). Consequently, molecules that inhibit aggregation of peptide may lead to …

Insulin fibrillation is a problem for diabetic patients that can occur during storage and
transport, as well as at the subcutaneous injection site, with loss of bioactivity, inflammation …

We have synthesized biocompatible ionic liquids (ILs) with choline as cation and amino
acids as anions to explore their potential towards prevention of fibrillation in insulin and the …