[HTML][HTML] The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

CJ Kim, R Romero, P Chaemsaithong… - American journal of …, 2015 - Elsevier
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …

[HTML][HTML] Cerebral palsy—trends in epidemiology and recent development in prenatal mechanisms of disease, treatment, and prevention

M Stavsky, O Mor, SA Mastrolia, S Greenbaum… - Frontiers in …, 2017 - frontiersin.org
Cerebral palsy (CP) is the most common motor disability in childhood. This syndrome is the
manifestation of intrauterine pathologies, intrapartum complications, and the postnatal …

Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance

CJ Kim, R Romero, P Chaemsaithong… - American journal of …, 2015 - Elsevier
Chronic inflammatory lesions of the placenta are characterized by the infiltration of the organ
by lymphocytes, plasma cells, and/or macrophages and may result from infections (viral …

Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics

KR Theis, R Romero, AD Winters, JM Greenberg… - American journal of …, 2019 - Elsevier
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …

[HTML][HTML] Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders

S Dash, YA Syed, MR Khan - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …

Maternal age and risk of labor and delivery complications

PA Cavazos-Rehg, MJ Krauss, EL Spitznagel… - Maternal and child …, 2015 - Springer
We utilized an updated nationally representative database to examine associations between
maternal age and prevalence of maternal morbidity during complications of labor and …

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

R Romero, J Miranda, P Chaemsaithong… - The journal of …, 2015 - Taylor & Francis
Objective: The objectives of this study were to:(1) determine the amniotic fluid (AF)
microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) …

Diagnosis and management of clinical chorioamnionitis

ATN Tita, WW Andrews - Clinics in perinatology, 2010 - perinatology.theclinics.com
Chorioamnionitis is a common complication of pregnancy associated with significant
maternal, perinatal, and long-term adverse outcomes. Adverse maternal outcomes include …

[HTML][HTML] The immune consequences of preterm birth

JM Melville, TJM Moss - Frontiers in neuroscience, 2013 - frontiersin.org
Preterm birth occurs in 11% of live births globally and accounts for 35% of all newborn
deaths. Preterm newborns have immature immune systems, with reduced innate and …