Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk
factor for development of obesity and its complications, such as fatty liver disease and …

Primary liver cancer is the third leading cause of cancer-related death worldwide. Most
patients are diagnosed at late stages with poor prognosis; thus, identification of modifiable …

Objective High fructose consumption exacerbates purine degradation and intestinal
dysbiosis, which are closely related to the development of hyperuricemia. Probiotics are …

AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis
and a central player in glucose and lipid metabolism, is potentially implicated in the …

Human studies support the relationship between high intake of fructose-sweetened
beverages and type 2 diabetes, but there is a debate on whether this effect is fructose …

The excessive intake of fructose in the regular human diet could be related to global
increases in metabolic disorders. Sugar-sweetened soft drinks, mostly consumed by …

Alzheimer's disease (AD) is the general consequence of dementia and is diagnostic
neuropathology by the cumulation of amyloid-beta (Aβ) protein aggregates, which are …

Abstract High-fructose corn syrup-55 (HFCS-55) has been suggested to be more lipogenic
than sucrose, which increases the risk for nonalcoholic fatty liver disease (NAFLD) and …

Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …

Significance: Nonalcoholic fatty liver disease (NAFLD) is a hepatic and systemic disorder
with a complex multifactorial pathogenesis. Owing to the rising incidence of obesity and …