The hepatitis delta virus: Replication and pathogenesis

C Sureau, F Negro - Journal of hepatology, 2016 - Elsevier
Hepatitis delta virus (HDV) is a defective virus and a satellite of the hepatitis B virus (HBV).
Its RNA genome is unique among animal viruses, but it shares common features with some …

Hepatitis delta virus

SA Hughes, H Wedemeyer, PM Harrison - The Lancet, 2011 - thelancet.com
Hepatitis delta virus (HDV) is a small, defective RNA virus that can infect only individuals
who have hepatitis B virus (HBV); worldwide more than 15 million people are co-infected …

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

C Koh, L Canini, H Dahari, X Zhao… - The Lancet Infectious …, 2015 - thelancet.com
Background Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory.
Prenylation is essential for HDV and inhibition abrogates HDV production in experimental …

[HTML][HTML] A review on hepatitis D: From virology to new therapies

N Mentha, S Clément, F Negro, D Alfaiate - Journal of advanced research, 2019 - Elsevier
Hepatitis delta virus (HDV) is a defective virus that requires the hepatitis B virus (HBV) to
complete its life cycle in human hepatocytes. HDV virions contain an envelope incorporating …

Hepatitis delta virus: insights into a peculiar pathogen and novel treatment options

FA Lempp, Y Ni, S Urban - Nature reviews Gastroenterology & …, 2016 - nature.com
Chronic hepatitis D is the most severe form of viral hepatitis, affecting∼ 20 million HBV-
infected people worldwide. The causative agent, hepatitis delta virus (HDV), is a unique …

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes

Z Zhang, C Filzmayer, Y Ni, H Sültmann, P Mutz… - Journal of …, 2018 - Elsevier
Background & Aims Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most
severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown …

Enveloped viruses distinct from HBV induce dissemination of hepatitis D virus in vivo

J Perez-Vargas, F Amirache, B Boson, C Mialon… - Nature …, 2019 - nature.com
Hepatitis D virus (HDV) doesn't encode envelope proteins for packaging of its
ribonucleoprotein (RNP) and typically relies on the surface glycoproteins (GPs) from …

[HTML][HTML] Hepatitis delta virus

JM Taylor - Virology, 2006 - Elsevier
Hepatitis delta virus (HDV) is a sub-viral agent that is dependent for its life cycle on hepatitis
B virus (HBV). The help it obtains from HBV is limited to the sharing of envelope proteins …

Pathogenesis of and new therapies for hepatitis D

C Koh, T Heller, JS Glenn - Gastroenterology, 2019 - Elsevier
Hepatitis delta virus (HDV) infection of humans was first reported in 1977, and now it is now
estimated that 15–20 million people are infected worldwide. Infection with HDV can be an …

[HTML][HTML] Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates

W Wang, FA Lempp, F Schlund, L Walter… - Journal of …, 2021 - Elsevier
Abstract Background & Aims Chronic hepatitis D virus (HDV) infections cause the most
severe form of viral hepatitis. HDV requires hepatitis B virus (HBV) envelope proteins for …