Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …

Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

Bacteria often encounter temperature fluctuations in their natural habitats and must adapt to
survive. The molecular response of bacteria to sudden temperature upshift or downshift is …

The Gram-negative envelope is a complex structure that consists of the inner membrane, the
periplasm, peptidoglycan and the outer membrane, and protects the bacterial cell from the …

Bacteria can rapidly and reversibly respond to changing environments via complex
transcriptional and post-transcriptional regulatory mechanisms. Many of these adaptations …

Bacterial transcriptional networks consist of hundreds of transcription factors and thousands
of promoters. However, the true complexity of transcription in a bacterial pathogen and the …

Understanding RNA processing and turnover requires knowledge of cleavages by major
endoribonucleases within a living cell. We have employed TIER-seq (transiently inactivating …

Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to
play critical regulatory roles in many processes. The major families of sRNAs include true …

Under conditions of nutrient deprivation or stress, or as cells enter stationary phase,
Escherichia coli and related bacteria increase the accumulation of RpoS, a specialized …

A small RNA, RyhB, was found as part of a genomewide search for novel small RNAs in
Escherichia coli. The RyhB 90-nt RNA down-regulates a set of iron-storage and iron-using …