Diltiazem: a review of its pharmacological properties and therapeutic efficacy

M Chaffman, RN Brogden - Drugs, 1985 - Springer
Diltiazem 1 is an orally and intravenously active calcium channel blocking agent shown to
be an effective and well-tolerated treatment for stable angina and angina due to coronary …

Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications

PH Stone, EM ANTMAN, JE MULLER… - Annals of Internal …, 1980 - acpjournals.org
The calcium channel blocking agents have multiple hemodynamic effects that make them
potentially valuable in treating many cardiovascular disorders. They are potent dilators of …

Molecular interactions of polyvinyl chloride microplastics and beta-blockers (Diltiazem and Bisoprolol) and their effects on marine meiofauna: Combined in vivo and …

M Allouche, S Ishak, MB Ali, A Hedfi, M Almalki… - Journal of Hazardous …, 2022 - Elsevier
The ecotoxicological effects of beta-blockers (ie Diltiazem and Bisoprolol) and their
interactions with the microplastic polyvinyl chloride on marine meiofauna were tested in …

A role for the mitochondrial Na (+)-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria.

DA Cox, MA Matlib - Journal of Biological Chemistry, 1993 - ASBMB
The role of the Na (+)-Ca2+ exchanger of heart mitochondria in cellular functioning is not yet
clear. The objectives of this study were to investigate the effects of stimulation and inhibition …

Differential cardiovascular effects of calcium channel blocking agents: potential mechanisms

RW Millard, DA Lathrop, G Grupp, M Ashraf… - The American Journal of …, 1982 - Elsevier
The three major calcium channel blocking agents, diltiazem, nifedipine and verapamil,
inhibit calcium entry into excitable cells. Despite this apparent common action at the cell …

In the eye of the storm: mitochondrial damage during heart and brain ischaemia

V Borutaite, A Toleikis, GC Brown - The FEBS journal, 2013 - Wiley Online Library
We review research investigating mitochondrial damage during heart and brain ischaemia,
focusing on the mechanisms and consequences of ischaemia‐induced and/or reperfusion …

Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents

EJ Landon, RJ Naukam, BVR Sastry - Biochemical pharmacology, 1986 - Elsevier
Carbon tetrachloride, chloroform, dimethylnitrosamine, thioacetamide or acetaminophen
was each administered to rats in a single hepatotoxic dose. Nifedipine, verapamil or …

Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange

DA Cox, MA Matlib - Trends in pharmacological sciences, 1993 - cell.com
Evidence has accumulated in the past decade suggesting that Ca'+ acts as a second
messenger not only in the cytosol of the heart to regulate contractility, but also within the …

Calcium antagonists: definition and mode of action

WG Nayler, PH Poole-Wilson - Basic Research in Cardiology, 1981 - Springer
The term “calcium antagonist” has been used for more than a decade to describe a group of
drugs whose negative inotropism is overcome by calcium. Because this term lacks specificity …

CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons

KT Baron, SA Thayer - European journal of pharmacology, 1997 - Elsevier
The effects of 7-chloro-3, 5-dihydro-5-phenyl-1H-4, 1-benzothiazepine-2-on (CGP37157),
an inhibitor of mitochondrial Na+/Ca2+ exchange, on depolarization-induced intracellular …