Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected
or transformed target cell is a physically active structure capable of exerting mechanical …

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We
characterize herein how human primary CD4+ T cell functions are affected by stiffness within …

T cells are critical for protective immune responses to pathogens and tumors. The T-cell
receptor (TCR)–CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently …

The αβ T-cell receptor (TCR) on each T lymphocyte mediates exquisite specificity for a
particular foreign peptide bound to a major histocompatibility complex molecule (pMHC) …

T lymphocytes use surface α β T-cell receptors (TCRs) to recognize peptides bound to MHC
molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite specificity of high …

Immune cells identify and destroy tumors by recognizing cellular traits indicative of
oncogenic transformation. In this study, we found that myocardin-related transcription factors …

Mechanical forces have key roles in regulating activation of T cells and coordination of the
adaptive immune response. A recent example is the ability of T cells to sense the rigidity of …

Iron–dextran nanoparticles functionalized with T cell activating proteins have been used to
study T cell receptor (TCR) signaling. However, nanoparticle triggering of membrane …