Clinical presentation of osteoarthritis (OA) is dominated by pain during joint use and at rest.
OA pain is caused by aberrant functioning of a pathologically altered nervous system with …

Musculoskeletal pain in the elderly is common and disabling. As the conditions causing
rheumatic pain, including osteoarthritis, inflammatory arthritis and soft-tissue conditions such …

Objectives: To evaluate the effects of adjunctive pregabalin 300 mg/day versus placebo on
polysomnographic (PSG) variables in patients with well controlled partial seizures and …

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as
emotional distress. While total joint replacement is one of the most effective treatments …

Background: Despite exciting progress and growth in the understanding of molecular and
cellular mechanisms of chronic pain, osteoarthritis (OA) pain remains a challenging clinical …

Osteoarthritis (OA) is a major cause of pain and is characterized by loss of articular cartilage
integrity, synovitis and remodeling of subchondral bone. However, OA pain mechanisms …

Each month, subscribers to The Formulary Monograph Service receive five to six well-
documented monographs on drugs that are newly released or are in late phase 3 trials. The …

Neuropathic pain arises from pathology of sensory function in the peripheral nervous system
or central nervous system. Neuropathic pain usually results from damage to sensory nerves …

Different selective GABAA-ligands are in development to treat anxiety and sleep disorders.
The Central Nervous System (cNS) effects of various selective and non-selective (partial) …