Interleukin-8 (IL-8, CXCL8) is a pro-inflammatory chemokine produced by various cell types
to recruit leukocytes to sites of infection or tissue injury. Acquisition of IL-8 and/or its …

Congenital heart disease (CHD) is the most common congenital anomaly in newborn
babies. Cardiac malformations have been produced in multiple experimental animal …

The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the
ability to differentiate into virtually all adult cell types are not well understood. Polycomb …

We present a CRISPR/Cas9 genome-editing strategy to systematically tag endogenous
proteins with fluorescent tags in human induced pluripotent stem cells (hiPSC). To date, we …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

The T-box family of transcription factors exhibits widespread involvement throughout
development in all metazoans. T-box proteins are characterized by a DNA-binding motif …

Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in
neoplastic development. Their oncogenic function might be associated with their well …

The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …

Chordomas are malignant tumours that occur along the spine and are thought to derive from
notochordal remnants. There is significant morphological variability between and within …

Chordoma is a primary bone cancer with no approved therapy. The identification of
therapeutic targets in this disease has been challenging due to the infrequent occurrence of …