Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex

A Macagno, NL Bernasconi, F Vanzetta… - Journal of …, 2010 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a widely circulating pathogen that causes severe
disease in immunocompromised patients and infected fetuses. By immortalizing memory B …

Interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship

G Rossini, C Cerboni, A Santoni… - Mediators of …, 2012 - Wiley Online Library
The interaction between human cytomegalovirus (HCMV) and its host is a complex process
that begins with viral attachment and entry into host cells, culminating in the development of …

[HTML][HTML] Monoclonal antibodies: Principles and applications of immmunodiagnosis and immunotherapy for hepatitis C virus

A Tabll, AT Abbas, S El-Kafrawy… - World journal of …, 2015 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a major health problem worldwide. Early detection of the infection
will help better management of the infected cases. The monoclonal antibodies (mAb) of mice …

Chikungunya virus envelope-specific human monoclonal antibodies with broad neutralization potency

L Warter, CY Lee, R Thiagarajan… - The Journal of …, 2011 - journals.aai.org
Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics in Africa
and Asia. Infection by CHIKV is often characterized by long-lasting, incapacitating arthritis …

Early inhibitors of human cytomegalovirus: state-of-art and therapeutic perspectives

B Mercorelli, D Lembo, G Palù, A Loregian - Pharmacology & therapeutics, 2011 - Elsevier
Human cytomegalovirus (HCMV) infection is associated with severe morbidity and mortality
in immunocompromised individuals, mainly transplant recipients and AIDS patients, and is …

Epitope specificity determines pathogenicity and detectability of anti–platelet‐derived growth factor receptor α autoantibodies in systemic sclerosis

G Moroncini, A Grieco, G Nacci, C Paolini… - Arthritis & …, 2015 - Wiley Online Library
Objective To identify the epitopes recognized by autoantibodies targeting platelet‐derived
growth factor receptor α (PDGFRα) in systemic sclerosis (SSc) and develop novel assays for …

Human antibody technology and the development of antibodies against cytomegalovirus

M Ohlin, C Söderberg-Nauclér - Molecular Immunology, 2015 - Elsevier
Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the
population. It may cause severe disease in immunocompromised individuals, is linked to …

A novel method for making human monoclonal antibodies

J Fraussen, K Vrolix, P Martinez-Martinez, M Losen… - Journal of …, 2010 - Elsevier
We have developed a B cell immortalization method for low B cell numbers per well using
simultaneous B cell stimulation by CpG2006 and B cell infection by Epstein-Barr virus (EBV) …

Agmatine-Containing Poly(amidoamine)s as a Novel Class of Antiviral Macromolecules: Structural Properties and In Vitro Evaluation of Infectivity Inhibition

M Donalisio, E Ranucci, V Cagno, A Civra… - Antimicrobial Agents …, 2014 - Am Soc Microbiol
ABSTRACT Poly (amidoamine) s (PAAs) are multifunctional tert-amine polymers endowed
with high structural versatility. Here we report on the screening of a minilibrary of PAAs …

Human cytomegalovirus neutralising antibodies and use thereof

A Lanzavecchia, A Macagno - US Patent 7,947,274, 2011 - Google Patents
The invention relates to neutralizing antibodies and antibody fragments having high potency
in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for a …