This review identifies some key concepts of muscle regeneration, viewed from perspectives
of classical and modern research. Early insights noted the pattern and sequence of …

State of the art techniques have been developed to isolate and analyze cells from various
tissues, aiming to capture their in vivo state. However, the majority of cell isolation protocols …

Muscle satellite cells are normally quiescent but are rapidly activated following muscle
damage. Here, we investigated whether damaged myofibers influence the activation of …

The aim of our work was to develop a protocol enabling a derivation of mesenchymal
stem/stromal cell (MSC) subpopulation with increased expression of pluripotent and neural …

Signaling interactions are important during skeletal muscle regeneration, where muscle
cells in distinct states (quiescent, reactivated, proliferating and differentiated) must …

Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells
and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium …

Several studies have suggested that bone marrow stromal steam cells (BMSC) exist in a
quiescent state (G0) within the in vivo niche; however, an explicit analysis of the biology of …

Skeletal muscle stem cells, originally termed satellite cells for their position adjacent to
differentiated muscle fibers, are absolutely required for the process of skeletal muscle repair …

Background During skeletal muscle regeneration, satellite stem cells use distinct pathways
to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic …

Stem cells in vivo can transit between quiescence and activation, two metabolically distinct
states. It is increasingly appreciated that cell metabolism assumes profound roles in stem …