As an indispensable component of recombinant fusion proteins, linkers have shown
increasing importance in the construction of stable, bioactive fusion proteins. This review …

In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Molecular dynamics (MD) simulations have become increasingly popular in studying the
motions and functions of biomolecules. The accuracy of the simulation, however, is highly …

The average globular protein contains 30% α-helix, the most common type of secondary
structure. Some amino acids occur more frequently in α-helices than others; this tendency is …

By far the largest proportion of the Earth's biosphere is comprised of organisms that thrive in
cold environments (psychrophiles). Their ability to proliferate in the cold is predicated on a …

Recent advances in protein engineering have come from creating multi-functional chimeric
proteins containing modules from various proteins. These modules are typically joined via …

The construction of complex protein folds relies on the precise conversion of a linear
polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link …

Recent advances in computational techniques have allowed the design of precise side-
chain packing in proteins with predetermined, naturally occurring backbone structures …

This paper surveys the emerging role of statistical mechanics and polymer theory in protein
folding. In the polymer perspective, the folding code is more a solvation code than a code of …

▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …