The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the
pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream …

Adenovirus (AdVs) is the viral vector of choice in vaccines and oncolytic applications owing
to its high transduction activity and inherent immunogenicity. For decades, AdV isolation has …

The efficiency with which polycationic peptides penetrate the cytosol depends on the
number and overall patterning of arginine residues. While general trends and unusually …

Nowadays, treatment with specific antivenins is considered the only cure for snakebites
accidents. However, access to antivenom obstructs the successful implementation of the …

From the initial steps of early drug discovery, the traditional techniques, like docking, QSAR,
or molecular dynamics, have been used for decades identifying targets, ranking molecule …

Although peptides are used as affinity chromatography ligands, they could be digested by
proteases. Usually, peptide stability is evaluated in solution, which differs from the resin …

The venom of Crotalus durissus terrificus (Cdt) is a source of a wide variety of toxins, some
of them with interesting pharmacological applications. Of these toxins, the phospholipase A …

In this chapter, a protocol to design affinity chromatography matrices with short peptide
ligands immobilized for protein purification is described. The first step consists of the …

From the initial steps of early drug discovery, the traditional techniques, like docking, QSAR,
or molecular dynamics, have been used for decades identifying targets, ranking molecule …

The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the
pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream …