Forkhead box (FOX) proteins are transcriptional factors that regulate various cellular
processes. This minireview provides an overview of FOXA2 functions, with a special …

Cystic fibrosis (CF) lung disease is characterized by early and persistent mucus
accumulation and neutrophilic inflammation in the distal airways. Identification of the factors …

The primary purpose of pulmonary ventilation is to supply oxygen (O2) for sustained aerobic
respiration in multicellular organisms. However, a plethora of abiotic insults and airborne …

Rationale: The goal was to connect elements of idiopathic pulmonary fibrosis (IPF)
pathogenesis, including chronic endoplasmic reticulum stress in respiratory epithelia …

Existing animal models of cystic fibrosis (CF) have provided key insights into CF
pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or …

Background Airway mucus hypersecretion is one of the important pathological features of
chronic obstructive pulmonary disease (COPD). MUC5B is the main mucin expressed in the …

Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in
asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive …

The G/T transversion rs35705950, located approximately 3 kb upstream of the MUC5B start
site, is the cardinal risk factor for idiopathic pulmonary fibrosis (IPF). Here, we investigate the …

Electronic cigarettes (E-cigarettes, ECs) are electronic devices that heat a liquid–usually
comprising propylene glycol and glycerol, with or without nicotine and flavors, stored in …

Goblet cell metaplasia and mucus hypersecretion are observed in many pulmonary
diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic …