The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

Combining nanotechnology with other science disciplines is necessary to produce various
materials with nanoscale structural and functional information, which is nanoarchitectonics …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …

Lipids and the membranes they form are fundamental building blocks of cellular life, and
their geometry and chemical properties distinguish membranes from other cellular …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20
years ago. Since that time, phosphine probes have been used in myriad applications to tag …

Biomolecular engineering can be used to purposefully manipulate biomolecules, such as
peptides, proteins, nucleic acids and lipids, within the framework of the relations among their …

The incorporation of fluorine can not only significantly facilitate the study of proteins but also
potentially modulate their function. Though some biosynthetic methods allow global residue …

In pursuit of fast bioorthogonal reactions, reactive moieties have been increasingly
employed for selective labeling of biomolecules in living systems, posing a challenge in …