LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
The emerging role of lysophosphatidic acid in cancer
GB Mills, WH Moolenaar - Nature Reviews Cancer, 2003 - nature.com
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation,
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Phospholipid-based signaling in plants
HJG Meijer, T Munnik - Annual review of plant biology, 2003 - annualreviews.org
Phospholipids are emerging as novel second messengers in plant cells. They are rapidly
formed in response to a variety of stimuli via the activation of lipid kinases or …
formed in response to a variety of stimuli via the activation of lipid kinases or …
Altered lipid metabolism in brain injury and disorders
RM Adibhatla, JF Hatcher - Lipids in health and disease, 2008 - Springer
Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …
disorders, as this organ has the highest lipid concentration next to adipose tissue …
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors
H Ohta, K Sato, N Murata, A Damirin… - Molecular …, 2003 - ASPET
Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific
receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly …
receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly …
International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P),
are now recognized as important extracellular signaling molecules. These lipid mediators …
are now recognized as important extracellular signaling molecules. These lipid mediators …
[HTML][HTML] Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism
DM Zu Heringdorf, KH Jakobs - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA),
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse …
Lysophospholipid G protein-coupled receptors
B Anliker, J Chun - Journal of Biological Chemistry, 2004 - ASBMB
The many biological responses documented for lysophospholipids that include
lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to …
lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to …
Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques
Background—Lysophosphatidic acid (LPA) is a platelet-activating component of mildly
oxidized LDL (mox-LDL) and lipids isolated from human atherosclerotic plaques. Specific …
oxidized LDL (mox-LDL) and lipids isolated from human atherosclerotic plaques. Specific …