Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery

CM Zimmermann, D Baldassi, K Chan… - Journal of Controlled …, 2022 - Elsevier
While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently
undruggable targets which could potentially be treated with RNA therapeutics. Hence, local …

[HTML][HTML] Solidification and oral delivery of biologics to the colon-a review

KT Kopp, L Saerens, J Voorspoels… - European Journal of …, 2023 - Elsevier
The oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for
the treatment of colon related diseases has been the focus of increasing attention over the …

Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases

SP Carneiro, A Greco, E Chiesa, I Genta… - Expert opinion on drug …, 2023 - Taylor & Francis
Introduction Most lung diseases are serious conditions resulting from genetic and
environmental causes associated with high mortality and severe symptoms. Currently …

Development of a spray-dried formulation of peptide-DNA nanoparticles into a dry powder for pulmonary delivery using factorial design

M Munir, VL Kett, NJ Dunne, HO McCarthy - Pharmaceutical Research, 2022 - Springer
Background Gene therapy via pulmonary delivery holds the potential to treat various lung
pathologies. To date, spray drying has been the most promising method to produce …

Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient‐Free Dry Powder for Inhalation

S Emami, Z Hemmati, S Yaqoubi… - Advances in …, 2024 - Wiley Online Library
Curcumin has shown beneficial effects on pulmonary diseases with chronic inflammation or
abnormal inflammatory responses, including chronic obstructive pulmonary disease …

The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

JE Barranco-García, C Caicedo, EJ Jiménez-Regalado… - Particuology, 2024 - Elsevier
Using biopolymers as wall materials in spray drying poses challenges, particularly in
attaining flowability and thermal stability among their physicochemical properties. This paper …

[HTML][HTML] Formulation strategies, preparation methods, and devices for pulmonary delivery of biologics

K Berkenfeld, S Carneiro, C Corzo, F Laffleur… - European Journal of …, 2024 - Elsevier
Biological products, including vaccines, blood components, and recombinant therapeutic
proteins, are derived from natural sources such as humans, animals, or microorganisms and …

Treatment of idiopathic pulmonary fibrosis by inhaled silybin dry powder prepared via the nanosuspension spray drying technology

X Ma, K Xia, J Xie, B Yan, X Han, S Li… - ACS Pharmacology & …, 2023 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is a kind of life-threatening interstitial lung disease
characterized by progressive dyspnea with accurate pathogenesis unknown. At present …

Modern trends in the formulation of microparticles for lung delivery using porogens: methods, principles and examples

A Peštálová, J Gajdziok - Pharmaceutical Development and …, 2024 - Taylor & Francis
Inhalation drug administration is increasingly used for local pharmacotherapy of lung
disorders and as an alternative route for systemic drug delivery. Modern inhalation powder …

Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging

M Munir, H Setiawan, R Awaludin, VL Kett - Clinical and translational …, 2023 - Springer
Purpose The application of contrast and tracing agents is essential for lung imaging, as
indicated by the wide use in recent decades and the discovery of various new contrast and …