Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP

Y Lin, E Wagner, U Lächelt - Biomaterials Science, 2022 - pubs.rsc.org
Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Gold nanoparticles: construction for drug delivery and application in cancer immunotherapy

H Huang, R Liu, J Yang, J Dai, S Fan, J Pi, Y Wei… - Pharmaceutics, 2023 - mdpi.com
Cancer immunotherapy is an innovative treatment strategy to enhance the ability of the
immune system to recognize and eliminate cancer cells. However, dose limitations, low …

Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing

Z Iqbal, K Rehman, J Xia, M Shabbir, M Zaman… - Biomaterials …, 2023 - pubs.rsc.org
RISPR-Cas9 has exhibited enormous potential in gene therapy. It can perform genome
editing with single-nucleotide precision in various types of cell and tissue, providing a …

Alkaline phosphatase-controllable and red light-activated RNA modification approach for precise tumor suppression

J Fang, Y Feng, Y Zhang, A Wang, J Li… - Journal of the …, 2022 - ACS Publications
RNA interference (RNAi) has proved to be a promising modality for disease treatment.
However, the promise of conventional RNA therapeutics for clinical application is severely …

Gene and photothermal combination therapy: principle, materials, and amplified anticancer intervention

F Tang, A Ding, Y Xu, Y Ye, L Li, R Xie, W Huang - Small, 2024 - Wiley Online Library
Gene therapy (GT) and photothermal therapy (PTT) have emerged as promising alternatives
to chemotherapy and radiotherapy for cancer treatment, offering noninvasiveness and …

Recent advances in nanotechnology approaches for non-viral gene therapy

Y Jiang, M Fan, Z Yang, X Liu, Z Xu, S Liu… - Biomaterials …, 2022 - pubs.rsc.org
Gene therapy has shown great potential in the treatment of many diseases by
downregulating the expression of certain genes. The development of gene vectors as a …

DNA‐based nanoarchitectures as eminent vehicles for smart drug delivery systems

M Komiyama, N Shigi, K Ariga - Advanced Functional Materials, 2022 - Wiley Online Library
In order to cure diseases efficiently with minimal side effects in sophisticated medicine,
eminent drugs must be selectively delivered to diseased parts and allow to work only there …

Research progress of nanomedicine-based mild photothermal therapy in tumor

X He, S Zhang, Y Tian, W Cheng… - International Journal of …, 2023 - Taylor & Francis
With the booming development of nanomedicine, mild photothermal therapy (mPTT, 42–45°
C) has exhibited promising potential in tumor therapy. Compared with traditional PTT (> 50° …

Combinational Gene Therapy toward Cancer with Nanoplatform: Strategies and Principles

J Lin, X Wang, D Ni, Y Chen, C Chen, Y Liu - ACS Materials Au, 2023 - ACS Publications
Cancer remains a significant threat to human health. While numerous therapies have been
developed to combat the disease, traditional treatments such as chemotherapy and …

Exploring advanced CRISPR delivery technologies for therapeutic genome editing

N Rostami, MM Gomari, E Choupani, S Abkhiz… - Small …, 2024 - Wiley Online Library
The genetic material within cells plays a pivotal role in shaping the structure and function of
living organisms. Manipulating an organism's genome to correct inherited abnormalities or …