Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

After liver injury, regeneration occurs through self-replication of hepatocytes. In severe liver
injury, hepatocyte proliferation is impaired—a feature of human chronic liver disease,. It is …

Chronic diseases confer tissue and organ damage that reduce quality of life and are largely
refractory to therapy. Although stem cells hold promise for treating degenerative diseases …

The liver is thought to utilize facultative stem cells, also known as" oval cells" or" atypical
ductal cells"(ADCs), for regeneration following various types of injury. However, this notion …

Work over several decades has laid solid foundations for the advancement of liver cell
therapy. To date liver cell therapy in people has taken the form of hepatocyte transplantation …

How organ size is controlled in mammals is not currently understood. In Drosophila the
Hippo signaling pathway functions to suppress growth in imaginal discs and has been …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

The inflammatory response to chronic injury affects tissue regeneration and has become an
important factor influencing the prognosis of patients. In previous stem cell treatments, it was …

The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase
that is activated by several ligands leading to the activation of diverse signaling pathways …