Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are
the end product of a cell lineage which has to undergo a complex and precisely timed …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

Semaphorins, originally discovered as guidance cues for developing axons, are involved in
many processes that shape the nervous system during development, from neuronal …

Promoting remyelination to prevent/reduce neurodegeneration in patients with multiple
sclerosis (MS) is a major therapeutic goal. The longstanding view that the block of …

Abstract Nerve-glia (NG2) glia or oligodendrocyte precursor cells (OPCs) are distributed
throughout the gray and white matter and generate myelinating cells. OPCs in white matter …

Remyelination is the generation of new myelin sheaths after injury facilitated by processes of
differentiating oligodendrocyte precursor cells (OPCs). Although this repair phenomenon …

Oligodendrocyte precursor cells (OPCs) undergo an extensive and coordinated migration in
the developing CNS, using the pre-formed scaffold of developed blood vessels as their …

Failure of remyelination of multiple sclerosis (MS) lesions contributes to neurodegeneration
that correlates with chronic disability in patients. Currently, there are no available treatments …

The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, although …

Long considered merely a trophic and mechanical support to neurons, astrocytes have
progressively taken the center stage as their ability to react to acute and chronic …