BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

In this tutorial review, an effort towards presentation of a comprehensive account of the
recent developments on various kinds of artemisinin derivatives including artemisinin …

This review summarizes the importance and recent discoveries of the use of adamantane
derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) …

The development of new efficient therapeutics for the treatment of malaria and cancer is an
important endeavor. Over the past 15 years, much attention has been paid to the synthesis …

Many important bioactive compounds have been discovered from natural sources using
bioactivity-directed fractionation and isolation (BDFl)[Balunas MJ, Kinghorn AD (2005) Drug …

In our ongoing search for highly active hybrid molecules exceeding their parent compounds
in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard …

Malaria is an infectious disease that mainly affects children and pregnant women from
tropical countries. The mortality rate of people infected with malaria per year is enormous …

New pharmaceutically active compounds can be obtained by modification of existing drugs
to access more effective agents in the wake of drug resistance amongst others. To achieve …

Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …

Using predictions from heme− quinoline antimalarial complex structures, previous
modifications of chloroquine (CQ), and hypotheses for chloroquine resistance (CQR), we …