Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been
widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung …

Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a
variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of …

Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors
and correlates with poor prognosis. We developed the novel TROP2-directed antibody–drug …

The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …

ABSTRACT UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key
proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse …

Hyperbilirubinemia is an important clinical sign that often indicates severe hepatobiliary
disease of different etiologies. Inherited non-haemolytichyperbilirubinemic conditions …

Purpose: The presence of similar histologic subtypes of epithelial ovarian and endometrial
cancers has long been noted, although the relevance of this finding to pathogenesis and …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Objectives SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with
UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1A …

Human pluripotent stem cells (hPSCs) represent a novel source of hepatocytes for drug
metabolism studies and cell-based therapy for the treatment of liver diseases. These …