Advances in multiplexed imaging technologies have drastically improved our ability to
characterize healthy and diseased tissues at the single-cell level. Co-detection by indexing …

Single-cell sequencing approaches have transformed our understanding of stem cell
systems, including hematopoiesis and its niche within the bone marrow. Recent reports …

The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …

Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed
by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated …

Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with
poor prognosis and significant morbidity. Accumulating evidence indicates that cancer cells …

Defining the spatial architecture of hematopoiesis in the bone marrow is indispensable to
understand how this tissue ensures stepwise, balanced, differentiation to meet organism …

Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …

Aging leads to functional decline of the hematopoietic system, manifested by an increased
incidence of hematological disease in the elderly. Deterioration of hematopoietic integrity …

The bone marrow is the home of hematopoiesis and is therefore a hotspot for the
development of hematopoietic diseases. Complex interactions between the bone marrow …

Massive segmental bone defects (SBD) are mostly treated by removing the fibula and
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …