Numerous studies support a role of the microenvironment in maintenance of the leukemic
clone, as well as in treatment resistance. It is clear that disruption of the normal bone marrow …

Background and aims Vitamin D inadequacy is now an internationally recognized health
problem and pediatric cancer patients may be at even higher risk than healthy children. We …

The bone marrow niche is thought to act as a permissive microenvironment required for
emergence or progression of hematologic cancers. We hypothesized that osteoblasts …

Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the
bone marrow (BM) microenvironment or niche. These interactions provide instructive cues …

Background Prevalent vitamin D deficiency (VDD) and low bone mineral density (BMD)
have led to vitamin D supplementation for children with cancer, regardless vitamin D status …

Despite extensive research and development of new treatments, acute myeloid leukemia
(AML)-backbone therapy has remained essentially unchanged over the last decades and is …

Background: Patients with hemophilia may be at risk for developing reduced bone mineral
density (BMD) for a number of reasons such as recurrent hemoarthrosis and immobilization …

Background Systemic lupus erythematosus (SLE) patients have lower bone mineral density
(BMD) compared with healthy individuals because of general, genetic, disease and …

Objective: The aim of this study is to assess bone mineral status in children with epilepsy, on
different antiepileptic drugs (AEDs) regimen, using dual-energy X-ray absorptiometry (DXA) …

This retrospective chart review study aimed to assess vitamin D status and identify risk
factors associated with vitamin D deficiency and bone parameters in children with cancer at …