[PDF][PDF] Molecular improvements in microbial A-amylases for enhanced stability and catalytic efficiency

R Sindhu, P Binod, A Madhavan, US Beevi… - Bioresour …, 2017 - scholar9.com
Enzymes are finding wide applications in industries for the productions of bioproducts.
These biological catalysts are an indispensible component of biological reactions. The use …

Overview of strategies for developing high thermostability industrial enzymes: Discovery, mechanism, modification and challenges

H Wu, Q Chen, W Zhang, W Mu - Critical Reviews in Food Science …, 2023 - Taylor & Francis
Biocatalysts such as enzymes are environmentally friendly and have substrate specificity,
which are preferred in the production of various industrial products. However, the strict …

Hunt for α-amylase from metagenome and strategies to improve its thermostability: a systematic review

P Sharma, K Mondal, KC Mondal, N Thakur - World Journal of …, 2022 - Springer
With the advent of green chemistry, the use of enzymes in industrial processes serves as an
alternative to the conventional chemical catalysts. A high demand for sustainable processes …

Improvement of microbial α-amylase stability: strategic approaches

TB Dey, A Kumar, R Banerjee, P Chandna… - Process …, 2016 - Elsevier
Microbial α-amylase being a vital enzyme in industrial biotechnology, has also received
enormous attention in academic field. Although a huge number of α-amylases from different …

Recent advances in the synthesis and medicinal perspective of pyrazole-based α-amylase inhibitors as antidiabetic agents

R Khator, V Monga - Future Medicinal Chemistry, 2024 - Taylor & Francis
Diabetes is a serious health threat across the globe, claiming millions of lives worldwide.
Among the various strategies employed, inhibition of α-amylase is a therapeutic protocol for …

Defining structural and evolutionary modules in proteins: a community detection approach to explore sub-domain architecture

JS Hleap, E Susko, C Blouin - BMC structural biology, 2013 - Springer
Background Assessing protein modularity is important to understand protein evolution. Still
the question of the existence of a sub-domain modular architecture remains. We propose a …

The N‐Terminal Domain of the Pullulanase from Anoxybacillus sp. WB42 Modulates Enzyme Specificity and Thermostability

J Wang, Z Liu, Z Zhou - ChemBioChem, 2018 - Wiley Online Library
Anoxybacillus sp. WB42 pullulanase (PulWB42) is a novel thermophilic amylopullulanase
that was assigned to the glycoside hydrolase family 13 subfamily 14 (GH13_14) type I …

In Silico Rational Design and Protein Engineering of Disulfide Bridges of an α‐Amylase from Geobacillus sp. to Improve Thermostability

H Zhang, W Zhai, L Lin, P Wang, X Xu, W Wei… - Starch …, 2021 - Wiley Online Library
A thermostable α‐amylase gene (AmySN) from Geobacillus stearothermophilus DMSZ 456
with an open reading frame of 1446 bp, encoding 481 amino acids is cloned. The optimal …

[PDF][PDF] Enhancing thermostability of maltogenic amylase from Geobacillus sp. SK70 by single amino acid substitution

MR Sulong, TC Leow, R Noor, Z Raja… - International Journal of …, 2015 - researchgate.net
The economic viability of applying enzymes in industrial processes is often governed by
enzymes thermostability which represents key parameter in determining economic feasibility …

Contribution of domain B to the catalytic properties of a Flavobacteriaceae α-amylase

H Yin, L Zhang, Z Yang, S Li, X Nie, Y Wang… - Process …, 2018 - Elsevier
A mesophilic α-amylase (FSA) from Sinomicrobium sp. 5DNS001 is closely related with a
thermophilic Pyrococcus α-amylase (PWA) in glycoside hydrolase (GH) 13_7 subfamily. In …