The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

Further research on the contribution of the Ang-(1–7)/ACE2/Mas axis to cardiovascular
pathology will lead to the development of new pharmacological approaches resulting in the …

The two axes of the renin–angiotensin system include the classical ACE/Ang II/AT1 axis and
the counter-regulatory ACE2/Ang-(1-7)/Mas1 axis. ACE2 is a multifunctional …

The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2–
angiotensin-(1-7)–Mas axis [ACE2–Ang-(1-7)–Mas] in ischemic and hemorrhagic stroke has …

Angiotensin II (Ang II) is well-considered to be the principal effector of the renin–angiotensin
system (RAS), which binds with strong affinity to the angiotensin II type 1 (AT1R) and type 2 …

The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the
protective arms of the renin–angiotensin system (RAS), ie they both mediate tissue …