Fifty shades of brain: a review on the mechanical testing and modeling of brain tissue

S Budday, TC Ovaert, GA Holzapfel… - … Methods in Engineering, 2020 - Springer
Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

Tissue‐scale biomechanical testing of brain tissue for the calibration of nonlinear material models

J Faber, J Hinrichsen, A Greiner, N Reiter… - Current …, 2022 - Wiley Online Library
Brain tissue is one of the most complex and softest tissues in the human body. Due to its
ultrasoft and biphasic nature, it is difficult to control the deformation state during …

[HTML][HTML] The role of mechanics during brain development

S Budday, P Steinmann, E Kuhl - Journal of the Mechanics and Physics of …, 2014 - Elsevier
Convolutions are a classical hallmark of most mammalian brains. Brain surface morphology
is often associated with intelligence and closely correlated with neurological dysfunction …

Brain stiffens post mortem

J Weickenmeier, M Kurt, E Ozkaya, R de Rooij… - Journal of the …, 2018 - Elsevier
Alterations in brain rheology are increasingly recognized as a diagnostic marker for various
neurological conditions. Magnetic resonance elastography now allows us to assess brain …

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

S Gholampour, D Frim, B Yamini - Communications Biology, 2022 - nature.com
The unpredictable complexities in hydrocephalus shunt outcomes may be related to the
recovery behavior of brain tissue after shunting. The simulated cerebrospinal fluid (CSF) …

Regional mechanical properties of human brain tissue for computational models of traumatic brain injury

JD Finan, SN Sundaresh, BS Elkin, GM McKhann II… - Acta biomaterialia, 2017 - Elsevier
To determine viscoelastic shear moduli, stress relaxation indentation tests were performed
on samples of human brain tissue resected in the course of epilepsy surgery. Through the …

Effects of Different Types of Electric Fields on Mechanical Properties and Microstructure of Ex Vivo Porcine Brain Tissues

C Zhang, Y Li, S Huang, L Yang… - ACS Biomaterials Science …, 2022 - ACS Publications
Electrotherapy plays a crucial role in regulating neuronal activity. Nevertheless, the relevant
therapeutic mechanisms are still unclear; thus, the effects of electric fields on brain tissue's …

Poro-viscoelastic effects during biomechanical testing of human brain tissue

A Greiner, N Reiter, F Paulsen, GA Holzapfel… - Frontiers in …, 2021 - frontiersin.org
Brain tissue is one of the softest tissues in the human body and the quantification of its
mechanical properties has challenged scientists over the past decades. Associated …

A viscoelastic analysis of the P56 mouse brain under large-deformation dynamic indentation

DB MacManus, B Pierrat, JG Murphy, MD Gilchrist - Acta Biomaterialia, 2017 - Elsevier
The brain is a complex organ made up of many different functional and structural regions
consisting of different types of cells such as neurons and glia, as well as complex anatomical …

Localized characterization of brain tissue mechanical properties by needle induced cavitation rheology and volume controlled cavity expansion

AS Mijailovic, S Galarza, S Raayai-Ardakani… - Journal of the …, 2021 - Elsevier
Abstract Changes in the elastic properties of brain tissue have been correlated with injury,
cancers, and neurodegenerative diseases. However, discrepancies in the reported elastic …