Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular
signaling, in which lysine acetylation and methylation have been the historical focus of …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

The increasing interest in the Mediterranean diet hinges on its healthy and anti-ageing
properties. The composition of fatty acids, vitamins and polyphenols in olive oil, a key …

Metabolite sensing is one of the most fundamental biological processes. During evolution,
multilayered mechanisms developed to sense fluctuations in a wide spectrum of …

Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently
been attracting markedly increasing interest. Aging is marked by a systemic decrease in …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Highlights•Non-acetyl histone acylations are catalyzed by classical acetylation
modifiers.•Active site engagement of the acyl group determines acyl type-specific …