Abstract 3D in vitro model systems such as spheroids and organoids provide an opportunity
to extend the physiological understanding using recapitulated tissues that mimic …

Modifications of the composition or organization of the cancer cell membrane seem to be a
promising targeted therapy. This approach can significantly enhance drug uptake or …

Additive manufacturing has shown promising results in reconstructing three-dimensional
(3D) living tissues for various applications, including tissue engineering, regenerative …

This study focused on the effects of simulated microgravity (s-μg) on mechanical properties,
major cytoskeleton biopolymers, and morphology of endothelial cells (ECs). The structural …

The exploration of deep space or other bodies of the solar system, associated with a long
stay in microgravity or altered gravity, requires the development of fundamentally new …

Due to the cumbersome nature of performing real microgravity—spaceflight research
scientists have been searching for alternatives to perform simulated microgravity or partial …

The effect of the force field parallel to the surface of the scaffold plate on cell activity
(deformation, migration) has been studied in vitro. Cell orientation was aligned by …

Cells sense and react on changes of the mechanical properties of their environment and,
likewise, respond to external mechanical stress applied to them. However, whether the …

Human adipose stem cells (ASCs) hold great potential for regenerative medicine
approaches, including osteogenic regeneration of bone defects, that fail to heal …

Understanding how stem cells adapt to space flight conditions is fundamental for human
space missions and extraterrestrial settlement. We analyzed gene expression in boundary …