[HTML][HTML] Opening the black box: the promise and limitations of explainable machine learning in cardiology

J Petch, S Di, W Nelson - Canadian Journal of Cardiology, 2022 - Elsevier
Many clinicians remain wary of machine learning because of longstanding concerns about
“black box” models.“Black box” is shorthand for models that are sufficiently complex that they …

Emerging technologies for molecular diagnosis of sepsis

M Sinha, J Jupe, H Mack, TP Coleman… - Clinical microbiology …, 2018 - Am Soc Microbiol
Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

What clinicians want: contextualizing explainable machine learning for clinical end use

S Tonekaboni, S Joshi… - Machine learning …, 2019 - proceedings.mlr.press
Translating machine learning (ML) models effectively to clinical practice requires
establishing clinicians' trust. Explainability, or the ability of an ML model to justify its …

A machine learning algorithm to predict severe sepsis and septic shock: development, implementation, and impact on clinical practice

HM Giannini, JC Ginestra, C Chivers… - Critical care …, 2019 - journals.lww.com
Objectives: Develop and implement a machine learning algorithm to predict severe sepsis
and septic shock and evaluate the impact on clinical practice and patient outcomes. Design …

A targeted real-time early warning score (TREWScore) for septic shock

KE Henry, DN Hager, PJ Pronovost… - Science translational …, 2015 - science.org
Sepsis is a leading cause of death in the United States, with mortality highest among
patients who develop septic shock. Early aggressive treatment decreases morbidity and …

[HTML][HTML] Real-world integration of a sepsis deep learning technology into routine clinical care: implementation study

MP Sendak, W Ratliff, D Sarro, E Alderton… - JMIR medical …, 2020 - medinform.jmir.org
Background: Successful integrations of machine learning into routine clinical care are
exceedingly rare, and barriers to its adoption are poorly characterized in the literature …

A computational approach to early sepsis detection

JS Calvert, DA Price, UK Chettipally, CW Barton… - Computers in biology …, 2016 - Elsevier
Objective To develop high-performance early sepsis prediction technology for the general
patient population. Methods Retrospective analysis of adult patients admitted to the …

Comparison of early warning scoring systems for hospitalized patients with and without infection at risk for in-hospital mortality and transfer to the intensive care unit

VX Liu, Y Lu, KA Carey, ER Gilbert, M Afshar… - JAMA network …, 2020 - jamanetwork.com
Importance Risk scores used in early warning systems exist for general inpatients and
patients with suspected infection outside the intensive care unit (ICU), but their relative …

Delay within the 3-hour surviving sepsis campaign guideline on mortality for patients with severe sepsis and septic shock

L Pruinelli, BL Westra, P Yadav, A Hoff… - Critical care …, 2018 - journals.lww.com
Objectives: To specify when delays of specific 3-hour bundle Surviving Sepsis Campaign
guideline recommendations applied to severe sepsis or septic shock become harmful and …

Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data

AJ Masino, MC Harris, D Forsyth, S Ostapenko… - PloS one, 2019 - journals.plos.org
Background Rapid antibiotic administration is known to improve sepsis outcomes, however
early diagnosis remains challenging due to complex presentation. Our objective was to …