RNA helicases of the DEAD-box protein family have been shown to participate in every
aspect of RNA metabolism. They are present in most organisms where they work as RNA …

RNA helicases of the DEAD box and related DExD/H proteins form a very large superfamily
of proteins conserved from bacteria and viruses to humans. They have seven to eight …

Background Given the rarity of most single-gene Mendelian disorders, concerted efforts of
data exchange between clinical and scientific communities are critical to optimize molecular …

Human melanoma cells can be reprogrammed to terminally differentiate and irreversibly
lose proliferative capacity by appropriate pharmacological manipulation. Subtraction …

▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …

DEAD-box RNA helicases, which regulate various processes involving RNA, have two RecA-
like domains as a catalytic core to alter higher-order RNA structures. We determined the 2.2 …

Structural information on helicase proteins has expanded recently beyond the DNA
helicases Rep and PcrA, and the hepatitis C virus RNA helicase to include UvrB, members …

Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic
transformation and the activation of AP-1-dependent transcription required for …

DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …

The translation initiation step in eukaryotes is highly regulated and rate-limiting. During this
process, the 40S ribosomal subunit is usually recruited to the 5′ terminus of the mRNA. It …