Research progress of mTOR inhibitors
Y Chen, X Zhou - European journal of medicinal chemistry, 2020 - Elsevier
Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
Overview of research into mTOR inhibitors
B Mao, Q Zhang, L Ma, DS Zhao, P Zhao, P Yan - Molecules, 2022 - mdpi.com
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that belongs to the
phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family. The kinase exists in the …
phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family. The kinase exists in the …
Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment
X Peng, Z Sun, P Kuang, J Chen - European Journal of Medicinal Chemistry, 2020 - Elsevier
Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …
Judicious toggling of mTOR activity to combat insulin resistance and cancer: current evidence and perspectives
PS Ong, LZ Wang, X Dai, SH Tseng, SJ Loo… - Frontiers in …, 2016 - frontiersin.org
The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes,
mTORC1, and mTORC2, plays a central role in the regulation of cellular growth, metabolism …
mTORC1, and mTORC2, plays a central role in the regulation of cellular growth, metabolism …
Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors
T Xu, D Sun, Y Chen, L Ouyang - European journal of medicinal chemistry, 2020 - Elsevier
Abstract mTOR (mammalian target of rapamycin), which is a serine/threonine kinase, has
been well-established as being closely correlated with the occurrence of various human …
been well-established as being closely correlated with the occurrence of various human …
Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice
A Heredia, N Le, RB Gartenhaus… - Proceedings of the …, 2015 - National Acad Sciences
HIV necessitates host factors for successful completion of its life cycle. Mammalian target of
rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes …
rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes …
Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines
An electrochemical intramolecular oxytrifluoromethylation of N-tethered alkenyl alcohols
was developed providing straightforward access to CF3-containing morpholines derivatives …
was developed providing straightforward access to CF3-containing morpholines derivatives …
Targeting the mTOR pathway using novel ATP-competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma
AG Amin, SW Jeong, JL Gillick… - International …, 2021 - spandidos-publications.com
Mechanistic target of rapamycin (mTOR), which functions via two multiprotein complexes
termed mTORC1 and mTORC2, is positioned in the canonical phosphoinositide 3-kinase …
termed mTORC1 and mTORC2, is positioned in the canonical phosphoinositide 3-kinase …
Defining the role of mTOR pathway in the regulation of stem cells of glioblastoma
M Jhanwar-Uniyal, O Gellerson, J Bree, M Das… - Advances in Biological …, 2023 - Elsevier
The mechanistic target of rapamycin (mTOR), a serine/threonine kinase, functions by
forming two multiprotein complexes termed mTORC1 and mTORC2. Glioblastoma (GBM) is …
forming two multiprotein complexes termed mTORC1 and mTORC2. Glioblastoma (GBM) is …
Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets
M Jhanwar-Uniyal, SL Zeller, E Spirollari, M Das… - Cells, 2024 - mdpi.com
The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions via
its discrete binding partners to form two multiprotein complexes, mTOR complex 1 and 2 …
its discrete binding partners to form two multiprotein complexes, mTOR complex 1 and 2 …