Transcriptional regulatory network of high-value active ingredients in medicinal plants

H Zheng, X Fu, J Shao, Y Tang, M Yu, L Li… - Trends in Plant …, 2023 - cell.com
High-value active ingredients in medicinal plants have attracted research attention because
of their benefits for human health, such as the antimalarial artemisinin, anticardiovascular …

Hairy roots: An untapped potential for production of plant products

KJ Morey, CAM Peebles - Frontiers in Plant Science, 2022 - frontiersin.org
While plants are an abundant source of valuable natural products, it is often challenging to
produce those products for commercial application. Often organic synthesis is too expensive …

A differentially regulated AP 2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in …

P Paul, SK Singh, B Patra, X Sui, S Pattanaik… - New …, 2017 - Wiley Online Library
Catharanthus roseus produces bioactive terpenoid indole alkaloids (TIA s), including the
chemotherapeutics, vincristine and vinblastine. Transcriptional regulation of TIA …

A critical review on use of Agrobacterium rhizogenes and their associated binary vectors for plant transformation

B Bahramnejad, M Naji, R Bose, S Jha - Biotechnology Advances, 2019 - Elsevier
Agrobacterium rhizogenes, along with A. tumefaciens, has been used to affect genetic
transformation in plants for many years. Detailed studies conducted in the past have …

Putative genes in alkaloid biosynthesis identified in Dendrobium officinale by correlating the contents of major bioactive metabolites with genes expression between …

Z Wang, W Jiang, Y Liu, X Meng, X Su, M Cao, L Wu… - BMC genomics, 2021 - Springer
Background Dendrobium officinale, an endangered Chinese herb, possesses extensive
therapeutic effects and contains bioactive ingredients such as major polysaccharides …

UPLC/MS-based untargeted metabolomics reveals the changes of metabolites profile of Salvia miltiorrhiza bunge during Sweating processing

M Cao, Y Liu, W Jiang, X Meng, W Zhang, W Chen… - Scientific Reports, 2020 - nature.com
Salvia miltiorrhiza has numerous compounds with extensive clinical application.“Sweating”,
a processing method of Traditional Chinese Medicine (TCM), results in great changes in …

Transcription factors in alkaloid engineering

Y Yamada, F Sato - Biomolecules, 2021 - mdpi.com
Plants produce a large variety of low-molecular-weight and specialized secondary
compounds. Among them, nitrogen-containing alkaloids are the most biologically active and …

Cross-family transcription factor interaction between MYC2 and GBFs modulates terpenoid indole alkaloid biosynthesis

X Sui, SK Singh, B Patra… - Journal of …, 2018 - academic.oup.com
Biosynthesis of medicinally valuable terpenoid indole alkaloids (TIAs) in Catharanthus
roseus is regulated by transcriptional activators such as the basic helix–loop–helix factor …

Transcriptional Regulation and Transport of Terpenoid Indole Alkaloid in Catharanthus roseus: Exploration of New Research Directions

J Liu, J Cai, R Wang, S Yang - International journal of molecular sciences, 2016 - mdpi.com
As one of the model medicinal plants for exploration of biochemical pathways and molecular
biological questions on complex metabolic pathways, Catharanthus roseus synthesizes …

The miRNAome of Catharanthus roseus: identification, expression analysis, and potential roles of microRNAs in regulation of terpenoid indole alkaloid biosynthesis

EM Shen, SK Singh, JS Ghosh, B Patra, P Paul… - Scientific reports, 2017 - nature.com
MicroRNAs (miRNAs) regulate numerous crucial biological processes in plants. However,
information is limited on their involvement in the biosynthesis of specialized metabolites in …