Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers
an implantable, non-pharmacologic treatment for patients with intractable chronic pain …

Neuropathic pain caused by nerve injury or disease remains a major challenge for modern
medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are …

Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain
syndrome and silicone implant incompatibility syndrome are a subject of debate among …

BACKGROUND: Gut microbiota, a consortium of diverse microorganisms residing in the
gastrointestinal tract, has emerged as a key player in neuroinflammatory responses …

It has been 50years since Gross and Lapiere discovered collagenolytic activity during
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …

Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …

Multiple sclerosis (MS) is a multifactorial demyelinating disease characterized by
neurodegenerative events and autoimmune response against myelin component …

Chronic pain remains to be a clinical challenge and is recognized as a major health problem
with varying impacts on quality of life. Currently, the first-line therapy for chronic pain is …

Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the
central nervous system. Dysregulation of microglia has been critically implicated in the …

Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …