The role of sex and sex hormones in neurodegenerative diseases
E Vegeto, A Villa, S Della Torre, V Crippa… - Endocrine …, 2020 - academic.oup.com
Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
ULK1 and ULK2 regulate stress granule disassembly through phosphorylation and activation of VCP/p97
Disturbances in autophagy and stress granule dynamics have been implicated as potential
mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles …
mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles …
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice
R Prakasam, A Bonadiman, R Andreotti… - Nature …, 2023 - nature.com
Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …
Therapeutic strategies to target the androgen receptor
The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …
the support of male sexual-related functions, as well as in the progression of prostate …
An overview of next-generation androgen receptor-targeted therapeutics in development for the treatment of prostate cancer
Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …
Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity
Spinal and bulbar muscular atrophy (SBMA) is an X-linked, adult-onset neuromuscular
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …
condition caused by an abnormal polyglutamine (polyQ) tract expansion in androgen …
A magic drug target: Androgen receptor
D Li, W Zhou, J Pang, Q Tang, B Zhong… - Medicinal research …, 2019 - Wiley Online Library
Androgen receptor (AR) is closely associated with a group of hormone‐related diseases
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …
Eighty years of targeting androgen receptor activity in prostate cancer: the fight goes on
Simple Summary Prostate cancer is the second most common cancer in men world-wide,
with nearly 1.3 million new cases each year, and over the next twenty years the incidence …
with nearly 1.3 million new cases each year, and over the next twenty years the incidence …
Amorphous Fe0.8Mn0.2Ox-Catalyzed Four-Step Tandem Synthesis of Benzazoles from Alcohols and o-Substituted Anilines without Solvent
L Dong, J Qin, J Chen, M Chen, M Lv… - ACS Sustainable …, 2024 - ACS Publications
Benzazoles, as crucial intermediates, can be synthesized via a superior four-step tandem
catalytic process from benzyl alcohols and o-substituted anilines. However, the reported …
catalytic process from benzyl alcohols and o-substituted anilines. However, the reported …