JAK inhibitor selectivity: new opportunities, better drugs?

A Virtanen, FR Spinelli, JB Telliez, JJ O'Shea… - Nature Reviews …, 2024 - nature.com
Cytokines function as communication tools of the immune system, serving critical functions
in many biological responses and shaping the immune response. When cytokine production …

Markers of bronchiolitis obliterans syndrome after lung transplant: between old knowledge and future perspective

D Cavallaro, M Guerrieri, S Cattelan, G Fabbri, S Croce… - Biomedicines, 2022 - mdpi.com
Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is
characterized by airflow limitation and an obstructive spirometric pattern without high …

Pulmonary graft-versus-host disease and chronic lung allograft dysfunction: two sides of the same coin?

S Bos, H Beeckmans, A Vanstapel… - The Lancet …, 2022 - thelancet.com
Allogeneic haematopoietic stem-cell transplantation (HSCT) and lung transplantation are
both established life-saving treatment options for carefully selected patients with various …

Long‐Term Maintenance of Clinical Responses by Individual Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis Treated With Abatacept

HI Brunner, N Tzaribachev, I Louw… - Arthritis Care & …, 2023 - Wiley Online Library
Objective To investigate the frequency and trajectories of individual patients with
polyarticular‐course juvenile idiopathic arthritis (JIA) achieving novel composite end points …

Lung Transplantation: A Viable Option for Connective Tissue Disease?

N Zhang, S Liu, Z Zhang, Y Liu, L Mi… - Arthritis Care & …, 2023 - Wiley Online Library
Interstitial lung disease (ILD) and pulmonary hypertension (PH) caused by connective tissue
disease (CTD) are one of the main causes of morbidity and death in patients. Although the …

Immune dysregulation as a driver of bronchiolitis obliterans

K Deng, G Lu - Frontiers in Immunology, 2024 - frontiersin.org
Bronchiolitis obliterans (BO) is a disease characterized by airway obstruction and fibrosis
that can occur in all age groups. Bronchiolitis obliterans syndrome (BOS) is a clinical …

[HTML][HTML] Current trends in candidate selection, contraindications, and indications for lung transplantation

A Arjuna, MT Olson, R Walia - Journal of Thoracic Disease, 2021 - ncbi.nlm.nih.gov
Lung transplantation is an established treatment option that can improve quality of life and
prolong survival for select patients diagnosed with end-stage lung disease. Given the gaps …

Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT

M Koziński, D Oner, J Gwizdała… - Communications …, 2025 - nature.com
Abstract Background Bronchiolitis Obliterans Syndrome (BOS), a fibrotic airway disease that
may develop after lung transplantation, conventionally relies on pulmonary function tests …

A diagnostic nomogram for early prediction of post-infectious bronchiolitis obliterans in severe pneumonia

S Yan, C Sun, K Jiang - Journal of Inflammation Research, 2023 - Taylor & Francis
Objective The study aimed to set up and validate a predictive nomogram for post-infectious
bronchiolitis obliterans in severe pneumonia. Methods We retrospectively analyzed data of …

Collagen type IV Alpha 5 chain in bronchiolitis obliterans syndrome after lung transplant: the first evidence

M Armati, S Cattelan, M Guerrieri, M Messina, B Perea… - Lung, 2023 - Springer
Introduction Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and
is characterized by airflow limitation and an obstructive spirometry pattern without …