Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

New therapeutic approaches are required for secondary prevention of residual vascular risk
after stroke. Diverse sources of evidence support a causal role for inflammation in the …

The heart is the most vital organ of the human body; thus, its improper functioning has a
significant impact on human life. Coronary artery disease (CAD) is a disease of the coronary …

Background Inflammation contributes to unstable atherosclerotic plaque and stroke. In
randomised trials in patients with coronary disease, canukinumab (an interleukin-1B …

Background and Objectives Human genetic studies support a key role of interleukin-6 (IL-6)
in the pathogenesis of ischemic stroke. However, there are only limited data from …

Colchicine has shown potential therapeutic benefits in cardiovascular conditions owing to its
broad anti-inflammatory properties. Here, we performed a meta-analysis to determine the …

Embolic stroke of unknown source (ESUS) represents one in five ischemic strokes.
Ipsilateral non-stenotic carotid plaques are identified in 40% of all ESUS. In this narrative …

Background: Ischemic stroke is a leading cause of morbidity and mortality in neurological
diseases. Numerous studies have evaluated the efficacy and safety of ischemic stroke …

Coronary atherosclerotic heart disease is a serious threat to human health. The results of the
Canakinumab Anti-Inflammatory Thrombosis Outcome Study published in 2017 put an end …

Introduction Recent years have witnessed unprecedented progress in stroke care, but unmet
needs persist regarding the efficacy of acute treatment and secondary prevention. Novel …