Oligonucleotides (OGNs) are relatively new modalities that offer unique opportunities to
expand the therapeutic targets. Reliable and high-throughput bioanalytical methods are …

Therapeutic nucleic acids are various chemically modified RNA or DNA with different
functions, which mainly play roles at the gene level. Owing to its accurately targeting at …

Liquid chromatography-mass spectrometry has been widely implemented as a powerful tool
for providing in-depth characterization of nucleic acid therapeutic modalities, such as anti …

Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of
complex diseases, especially for conditions that lack efficacious treatment. The successful …

The success of the messenger RNA-based COVID-19 vaccines of Moderna and
Pfizer/BioNTech marks the beginning of a new chapter in modern medicine. However, the …

Abstract Background: Antisense oligonucleotide (ASO), an emerging modality in drug
research and development, demands accurate and sensitive bioanalysis to understand its …

Therapeutic oligonucleotides, such as antisense oligonucleotide (ASO) and small interfering
RNA (siRNA), are a new class of therapeutics rapidly growing in drug discovery and …

The present investigation showed that each of the three different liquid chromatography
modes may be successfully used for the qualitative analysis of nusinersen metabolites in a …

Oligonucleotides have many important applications, including as primers in polymerase
chain reactions and probes for DNA sequencing. They are proposed as a diagnostic and …

Nonspecific adsorption has been a consistent challenge in the analysis of oligonucleotides.
Nonspecific adsorption is a result of interactions between charged acidic analytes and …