Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

[HTML][HTML] Mitochondrial disorder and treatment of ischemic cardiomyopathy: potential and advantages of Chinese herbal medicine

X Chang, J Liu, Y Wang, X Guan, R Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Mitochondrial dysfunction is the main cause of damage to the pathological mechanism of
ischemic cardiomyopathy. In addition, mitochondrial dysfunction can also affect the …

Zishenhuoxue decoction-induced myocardial protection against ischemic injury through TMBIM6-VDAC1-mediated regulation of calcium homeostasis and …

X Chang, S Zhou, J Liu, Y Wang, X Guan, Q Wu, Z Liu… - Phytomedicine, 2024 - Elsevier
Background Zishenhuoxue decoction (ZSHX), a Chinese herbal medicine, exhibits
myocardial and vascular endothelial protective properties. The intricate regulatory …

Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions

X Pu, Q Zhang, J Liu, Y Wang, X Guan, Q Wu, Z Liu… - Phytomedicine, 2024 - Elsevier
Background There is currently no specific therapeutic drug available for heart failure in
clinical practice. Numerous studies have validated the efficacy of Ginsenoside Rb1, an …

The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis

S Lenhard, S Gerlich, A Khan, S Rödl… - Journal of Cell …, 2023 - rupress.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high
amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70 …

Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated …

J Wang, H Zhuang, L Jia, X He, S Zheng… - International …, 2024 - pmc.ncbi.nlm.nih.gov
This study investigated the mechanism by which NR4A1 regulates mitochondrial fission
factor (Mff)-related mitochondrial fission and FUN14 domain 1 (FUNDC1)-mediated …

Mechanisms of long COVID: An updated review

Y Liu, X Gu, H Li, H Zhang, J Xu - Chinese Medical Journal …, 2023 - mednexus.org
The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3
years, with an enormous impact on global health and economies. In some patients …

New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and …

Y Li, J Yu, R Li, H Zhou, X Chang - Cellular & Molecular Biology Letters, 2024 - Springer
Background Septic cardiomyopathy (SCM), a common cardiovascular comorbidity of sepsis,
has emerged among the leading causes of death in patients with sepsis. SCM's …

Quercetin inhibits necroptosis in cardiomyocytes after ischemia–reperfusion via DNA‐PKcs‐SIRT5‐orchestrated mitochondrial quality control

X Chang, Q Zhang, Y Huang, J Liu… - Phytotherapy …, 2024 - Wiley Online Library
We investigated the mechanism by which quercetin preserves mitochondrial quality control
(MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked …

COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability

Y Zhao, X Han, C Li, Y Liu, J Cheng… - Frontiers in …, 2023 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans
can lead to various degrees of tissue and organ damage, of which cardiovascular system …