[HTML][HTML] How integrins control breast biology

MA Glukhova, CH Streuli - Current opinion in cell biology, 2013 - Elsevier
This article explores new ideas about how the ECM-integrin axis controls normal and
malignant breast biology. We discuss the role of integrins in mammary stem cells, and how …

Integrin-α9β1 as a novel therapeutic target for refractory diseases: Recent progress and insights

S Xu, T Zhang, Z Cao, W Zhong, C Zhang, H Li… - Frontiers in …, 2021 - frontiersin.org
Integrins refer to heterodimers consisting of subunits α and β. They serve as receptors on
cell membranes and interact with extracellular ligands to mediate intracellular molecular …

SVEP1 is a human coronary artery disease locus that promotes atherosclerosis

IH Jung, JS Elenbaas, A Alisio, K Santana… - Science translational …, 2021 - science.org
A low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-
containing protein 1 (SVEP1), an extracellular matrix protein, is associated with risk of …

Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells

EN Alonso, M Orozco, AE Nieto… - Journal of medicinal …, 2013 - liebertpub.com
It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the
immune system and activating certain cells that attack cancer, including macrophages, T …

Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep

Y Arzik, M Kizilaslan, SN White, LMW Piel… - Scientific Reports, 2022 - nature.com
The aim of this study was to estimate genomic heritability and the impact that genetic
backgrounds have on blood parameters in Akkaraman sheep by conducting genome-wide …

Abnormal promoter DNA hypermethylation of the integrin, nidogen, and dystroglycan genes in breast cancer

VV Strelnikov, EB Kuznetsova, AS Tanas… - Scientific Reports, 2021 - nature.com
Cell transmembrane receptors and extracellular matrix components play a pivotal role in
regulating cell activity and providing for the concerted integration of cells in the tissue …

MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9

TJ Xu, P Qiu, YB Zhang, SY Yu, GM Xu, W Yang - Human cell, 2019 - Springer
Glioblastoma is a common malignant primary intracranial tumor characterized by rapid
invasive growth and a high recurrence rate after surgery. MicroRNAs (miRNAs) are involved …

PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs

L Herviou, A Kassambara, S Boireau, N Robert… - Clinical …, 2018 - Springer
Background Multiple myeloma (MM) is a malignant plasma cell disease with a poor survival,
characterized by the accumulation of myeloma cells (MMCs) within the bone marrow …

TDP-43 regulates cancer-associated microRNAs

X Chen, Z Fan, W McGee, M Chen, R Kong… - Protein & …, 2018 - academic.oup.com
Aberrant regulation of miRNA genes contributes to pathogenesis of a wide range of human
diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a RNA/DNA binding …

Long non-coding RNA HOXA11-AS modulates proliferation, apoptosis, metastasis and EMT in cutaneous melanoma cells partly via miR-152-3p/ITGA9 axis

Y Xu, J Zhang, Q Zhang, H Xu, L Liu - Cancer Management and …, 2021 - Taylor & Francis
Background Long non-coding RNA homeobox A11 antisense RNA (HOXA11-AS) was
showed to participate in the progression of different kinds of tumors, but the specific role of …