The Na+/Ca2+ exchanger (NCX) is an ion transporter that exchanges Na+ and Ca 2+ in
either Ca 2+ efflux or Ca 2+ influx mode, depending on membrane potential and …

The Na+/Ca2+ exchanger (NCX) is a bidirectional transporter that normally extrudes Ca2+
from the cell (forward mode), but also brings Ca2+ into the cell (reverse mode) under special …

Abstract Objective Pulmonary veins (PVs) are the most important focus for generation of
atrial fibrillation. The Na+/Ca2+ exchange (NCX) current is important in PV electrical activity …

Background In this study the effects of a new, highly selective sodium-calcium exchanger
(NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell …

Abstract SEA0400 and KB-R7943 are compounds synthesised to block transsarcolemmal
Na+/Ca 2+ exchange current (I Na/Ca); however, they Have also been shown to inhibit L …

The search for alternative anti-arrhythmic strategies is fueled by an unmet medical need as
well as by the opportunities arising from identification of novel targets and novel drugs …

Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-
economic burden. Calcium (Ca2+) dysregulation is key hallmark of the failing myocardium …

Life-long stable heart function requires a critical balance of intracellular Ca2+. Several ion
channels and pumps cooperate in a complex machinery that controls the influx, release, and …

Using the whole-cell voltage clamp, we examined acute effects of various agents on Na+/Ca
2+ exchange current (I NCX) in guinea-pig cardiac ventricular cells and transfected cells …

ABSTRACT The Na+–Ca2+ exchange (NCX) system plays a pivotal role in regulating
intracellular Ca2+ concentration in cardiomyocytes, neuronal cells, kidney and a variety of …