Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Despite tremendous investments in understanding the complex molecular mechanisms
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …

Biochemical and genetic evidence establishes a central role of the amyloid precursor
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive
impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We …

Background Alzheimer's disease (AD) neuropathology is associated with
neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering …

The synapse is the locus of plasticity where short-term alterations in synaptic strength are
converted to long-lasting memories. In addition to the presynaptic terminal and the …

We elucidated the molecular fingerprint of vulnerable excitatory neurons within select
cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and …

The increase of oligomeric amyloid-beta (oAβ) has been related to synaptic dysfunction,
thought to be the earliest event in Alzheimer's disease pathophysiology. Conversely, the …

Synaptic dysfunction and synapse loss are key features of Alzheimer's pathogenesis.
Previously, we showed an essential function of APP and APLP2 for synaptic plasticity …