Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response
M Ashrafizadeh, CD Mohan… - Medicinal research …, 2023 - Wiley Online Library
Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …
microRNA-181 serves as a dual-role regulator in the development of human cancers
MicroRNAs (miRNAs) as the regulatory short noncoding RNAs are involved in a wide array
of cellular and molecular processes. They negatively regulate gene expression and their …
of cellular and molecular processes. They negatively regulate gene expression and their …
Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma
J Yu, Q Xu, Z Wang, Y Yang, L Zhang, J Ma, S Sun… - Journal of …, 2018 - Elsevier
Background & Aims In recent years, circular RNAs (circRNAs) have been shown to have
critical regulatory roles in cancer biology. However, the contributions of circRNAs to …
critical regulatory roles in cancer biology. However, the contributions of circRNAs to …
A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability
The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the
function of majority of them is poorly understood. Aberrant expression of a significant …
function of majority of them is poorly understood. Aberrant expression of a significant …
Exosomal microRNA-21-5p mediates mesenchymal stem cell paracrine effects on human cardiac tissue contractility
J Mayourian, DK Ceholski, PA Gorski… - Circulation …, 2018 - Am Heart Assoc
Rationale: The promising clinical benefits of delivering human mesenchymal stem cells
(hMSCs) for treating heart disease warrant a better understanding of underlying …
(hMSCs) for treating heart disease warrant a better understanding of underlying …
miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1
Background Colorectal cancer (CRC) is a major worldwide health problem due to its high
prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor …
prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor …
The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
Background Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the
mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for …
mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for …
Oncogenic miRNAs and target therapies in colorectal cancer
A Saberinia, A Alinezhad, F Jafari, S Soltany… - Clinica Chimica …, 2020 - Elsevier
OncomiRNAs involved in human colorectal cancer (CRC) are capable of suppressing the
expression of their targets via cleavage or translational arrest. Therefore, an improved …
expression of their targets via cleavage or translational arrest. Therefore, an improved …
Development of novel therapeutic agents by inhibition of oncogenic microRNAs
MicroRNAs (miRs, miRNAs) are regulatory small noncoding RNAs, with their roles already
confirmed to be important for post-transcriptional regulation of gene expression affecting cell …
confirmed to be important for post-transcriptional regulation of gene expression affecting cell …
LncRNA HAND2-AS1 inhibits 5-fluorouracil resistance by modulating miR-20a/PDCD4 axis in colorectal cancer
Z Jiang, L Li, Z Hou, W Liu, H Wang, T Zhou, Y Li… - Cellular signalling, 2020 - Elsevier
Background Chemoresistance is one of the main obstacles in the therapy of human cancers,
including colorectal cancer (CRC). Long non-coding RNA heart and neural crest derivatives …
including colorectal cancer (CRC). Long non-coding RNA heart and neural crest derivatives …