The role of microRNAs in glucocorticoid action

SA Clayton, SW Jones, M Kurowska-Stolarska… - Journal of Biological …, 2018 - ASBMB
Glucocorticoids (GCs) are steroids with profound anti-inflammatory and immunomodulatory
activities. Synthetic GCs are widely used for managing chronic inflammatory and …

MicroRNAs and exosomes: Small molecules with big actions in multiple myeloma pathogenesis

MH Pourhanifeh, M Mahjoubin‐Tehran, A Shafiee… - IUBMB …, 2020 - Wiley Online Library
Multiple myeloma (MM), an incurable hematologic malignancy of plasma cells increasing in
the bone marrow (BM), has a complex microenvironment made to support proliferation …

Activation of the glucocorticoid receptor in acute inflammation: the SEDIGRAM concept

K De Bosscher, IM Beck, D Ratman, WV Berghe… - Trends in …, 2016 - cell.com
Since the 1950s, glucocorticoids (GCs) have been a mainstay therapy for acute and chronic
inflammatory disorders, although adverse effects limit their chronic use. Following the notion …

[HTML][HTML] Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

D Clarisse, F Offner, K De Bosscher - … et Biophysica Acta (BBA)-Reviews on …, 2020 - Elsevier
Glucocorticoids are essential drugs in the treatment protocols of lymphoid malignancies.
These steroidal hormones trigger apoptosis of the malignant cells by binding to the …

Circulating miRNAs as potential biomarkers in myasthenia gravis: tools for personalized medicine

L Sabre, T Punga, AR Punga - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease caused by antibodies which attack
receptors at the neuromuscular junction. One of the main difficulties in predicting the clinical …

miR-146a in myasthenia gravis thymus bridges innate immunity with autoimmunity and is linked to therapeutic effects of corticosteroids

F Bortone, L Scandiffio, S Marcuzzo… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptor (TLR)-mediated innate immune responses are critically involved in the
pathogenesis of myasthenia gravis (MG), an autoimmune disorder affecting neuromuscular …

MicroRNAs as a potential new preventive approach in the transition from asymptomatic to symptomatic multiple myeloma disease

V Desantis, AG Solimando, I Saltarella, A Sacco… - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma (MM) is the second most common haematologic
malignancy, and it remains an incurable disease despite the advances of novel therapies. It …

Exploring the nexus of nuclear receptors in hematological malignancies

MK Manickasamy, A Sajeev… - Cellular and Molecular …, 2024 - Springer
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood,
bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and …

[HTML][HTML] Suppression of mir-150–5p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis

Y Wang, J Qin, L Dong, C He, D Zhang, X Wu, T Li… - Molecular …, 2023 - Elsevier
Glucocorticoids have been widely used in the treatment of ulcerative colitis, but not all
patients benefit from this therapy due to hormone resistance. Mir-150–5p has been reported …

lncRNA-PRLB confers paclitaxel resistance of ovarian cancer cells by regulating RSF1/NF-κB signaling pathway

Y Zhao, L Hong - Cancer Biotherapy & Radiopharmaceuticals, 2021 - liebertpub.com
Background: Long noncoding RNA (lncRNA)-PRLB (progression-associated lncRNA in
breast cancer) has been identified to enhance the drug resistance of breast cancer cells. In …