The CD300 family of molecules modulates a broad and diverse array of immune cell
processes via their paired activating and inhibitory receptor functions. The description that …

Alzheimer's disease is characterized by the accumulation of amyloid-beta in plaques,
aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation …

The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already …

Abstract Bridging integrator 1 (BIN1) is the second most prevalent genetic risk factor
identified by genome-wide association studies (GWAS) for late-onset Alzheimer's disease …

Microglia are implicated as primarily detrimental in pain models; however, they exist across
a continuum of states that contribute to homeostasis or pathology depending on timing and …

Lack of targeting and improper biodistribution are major flaws in current drug-based
therapies that prevent reaching high local concentrations of the therapeutic agent. Such …

Emerging evidences suggest that immune receptors participate in diverse microglial and
macrophage functions by regulating their immunometabolism, inflammatory phenotype and …

Background It has recently become evident that activating/inhibitory cell surface immune
receptors play a critical role in regulating immune and inflammatory processes in the central …

Noroviruses are a leading cause of gastrointestinal infection in humans and mice.
Understanding human norovirus (HuNoV) cell tropism has important implications for our …

A role for microglia in neuropsychiatric diseases, including major depressive disorder
(MDD), has been postulated. Regulation of microglial phenotype by immune receptors has …