Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …
molecules in the same crystal lattice that are physically connected by non-ionic and non …
Recent advances in pharmaceutical cocrystals: From bench to market
The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid
pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the …
pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the …
Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications
Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …
Pharmaceutical Co-crystals, Salts, and Co-amorphous Systems: A novel opportunity of hot-melt extrusion
Enhancing the solubility of active drug ingredients is a major challenge faced by scientists
and researchers. Different approaches have been explored for the enhancement of solubility …
and researchers. Different approaches have been explored for the enhancement of solubility …
Innovations in thermal processing: hot-melt extrusion and KinetiSol® dispersing
Thermal processing has gained much interest in the pharmaceutical industry, particularly for
the enhancement of solubility, bioavailability, and dissolution of active pharmaceutical …
the enhancement of solubility, bioavailability, and dissolution of active pharmaceutical …
Polymer-assisted aripiprazole–adipic acid cocrystals produced by hot melt extrusion techniques
Pharmaceutical cocrystals offer a promising strategy to increase the solubility and
dissolution rate of poorly soluble drugs. However, their manufacturing process requires a …
dissolution rate of poorly soluble drugs. However, their manufacturing process requires a …
A comparative assessment of cocrystal and amorphous solid dispersion printlets developed by hot melt extrusion paired fused deposition modeling for dissolution …
The primary focus of the research is to study the role of cocrystal and amorphous solid
dispersion approaches for enhancing solubility and preserving the stability of a poorly …
dispersion approaches for enhancing solubility and preserving the stability of a poorly …
In-line Raman spectroscopy and chemometrics for monitoring cocrystallisation using hot melt extrusion
The application of in-line Raman spectroscopy to monitor the formation of a 1: 1 cocrystal of
ibuprofen (IBU) as a BCS class II drug and nicotinamide as coformer using hot-melt …
ibuprofen (IBU) as a BCS class II drug and nicotinamide as coformer using hot-melt …
Research on the powder classification and the key parameters affecting tablet qualities for direct compaction based on powder functional properties
Y Yu, L Zhao, X Lin, Y Wang, R Du, Y Feng - Advanced Powder …, 2021 - Elsevier
Direct compaction (DC) is the ideal method for tablet production. However, DC requires the
highest quality powder functional properties, such as good flowability, compressibility …
highest quality powder functional properties, such as good flowability, compressibility …
Hot-Melt extrusion: an emerging technique for solubility enhancement of poorly water-soluble drugs
The solubility of the drug is a significant aspect to be considered during manufacturing of
pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability …
pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability …