Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the
non-invasive investigation of tissue metabolism. The generally short T 1 values of 2 H …

Hyperpolarized carbon 13 MRI (13C MRI) is a novel imaging approach that can
noninvasively probe tissue metabolism in both normal and pathologic tissues. The process …

Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …

Tumour metabolism can be imaged with a novel imaging technique termed hyperpolarised
carbon-13 (13 C)-MRI using probes, ie, endogenously found molecules that are labeled with …

Our understanding of tumour biology has evolved over the past decades and cancer is now
viewed as a complex ecosystem with interactions between various cellular and non-cellular …

Hyperpolarised magnetic resonance imaging (HP-13C-MRI) has shown promise as a
clinical tool for detecting and characterising prostate cancer. Here we use a range of …

Hyperpolarization techniques increase nuclear spin polarization by more than four orders of
magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value …

Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance
(MR) and thus present fascinating new directions for research and applications with in vivo …

One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic
glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR …