DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the …

Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Enhancers are distal DNA elements believed to loop and contact promoters to control gene
expression. Recently, we found diffraction-sized transcriptional condensates at genes …

Tight control of the transcription process is essential for the correct spatial and temporal
gene expression pattern during development and in homeostasis. Enhancers are at the core …

The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are
unusually diverse with regard to their chromatin features, including histone modifications …

The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …

The inability to scalably and precisely measure the activity of developmental cis-regulatory
elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a …

Many genes are regulated by multiple enhancers that often simultaneously activate their
target gene. However, how individual enhancers collaborate to activate transcription is not …

Sox2 expression in mouse embryonic stem cells (mESCs) depends on a distal cluster of
DNase I hypersensitive sites (DHSs), but their individual contributions and degree of …

Transposable elements (TE) are repetitive genomic elements that harbor binding sites for
human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal …