Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …

INTRODUCTION Cells respond to their environment, make decisions, build structures, and
coordinate tasks. Underlying these processes are computational operations performed by …

Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays
in dynamic, living systems. A major critical challenge for this class of experiments is the …

Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental …

Stochastic fluctuations of molecule numbers are ubiquitous in biological systems. Important
examples include gene expression and enzymatic processes in living cells. Such systems …

Abstract The 'Standard European Vector Architecture'database (SEVA-DB, http://seva. cnb.
csic. es) was conceived as a user-friendly, web-based resource and a material clone …

Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and
environmental variation. However, even genetically identical cells in identical environments …

Elucidating the role of molecular stochasticity in cellular growth is central to understanding
phenotypic heterogeneity and the stability of cellular proliferation. The inherent stochasticity …

The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or
'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be …